1. 研究目的与意义（文献综述包含参考文献）
Introduction:Hepatitis B virus (HBV) is the major causative agent of hepatitis worldwide. According to World Health Organization (WHO), an estimated 240 million people globally have chronic HBV infection (http://www.who.int/mediacentre/factsheets/fs204/en/). HBV infection has been reported to result in liver cirrhosis, hepatic failure, or hepatocellular carcinoma (HCC), leading to about 780,000 deaths each year globally. HCC is the fifth most common cancer and the second cause of cancer-related deaths in the world, and nearly 53% of HCC is estimated to be related to HBV. Additionally, it is predicted that the risk of HCC increases by 5- to 15-fold in individuals who are chronically infected with HBV. Basic characteristics of study subjects:In the present study, 424 HBV-infected Saudi patients were investigated. Age of the patients was an associated risk factor for HCC development (p
2. 研究的基本内容、问题解决措施及方案
Risk Factor Analysis Liver Disease Stages Analysis Statistical Analyses Biomarker Analysis Non Invasive Biomarker Analysis High Profile Biomarker Future Work
